The Project

About the

The function of a protein depends on its ability to fold into its native state. Protein misfolding of cytosolic and membrane proteins has been linked to various human diseases, such as Alzheimer’s disease and cystic fibrosis, respectively. The EU-funded Twin4Promis project aims to set up a research and training hub in protein misfolding diseases to bridge the gap between the communities that study the misfolding of soluble and integral membrane proteins.

Partners wish to consolidate this research community and address challenges associated with isolation and characterisation of membrane proteins implicated in misfolding diseases. The results generated by the project will provide the groundwork for identifying novel molecules for therapeutic interventions in misfolding diseases associated with integral membrane proteins.

The specific objectives of the Twin4Promis project 

Project start date: November 1st, 2022.  Project duration: 36 months

Enhance the ability of the NHRF to disseminate and communicate the results of its research activities more effectively to the scientific community and the wider public, as well as its capacity to commercially exploit the Institute’s research output and promote technology transfer and high-tech entrepreneurship further to contribute to Greece’s Research & Innovation Strategy for Smart Specialization (RIS3) priorities

Reinforce the scientific excellence capacity and resources of the National Hellenic Research Foundation NHRF, improve the career development opportunities of its young scientists and raise its research profile in the field of protein misfolding diseases

Establish a new excellence hub in research, training and innovation on protein misfolding diseases

Strengthen the research management and organizational skills of the NHRF staff.


Work Packages