The function of a protein depends on its ability to fold into its native state. Protein misfolding of cytosolic and membrane proteins has been linked to various human diseases, such as Alzheimer’s disease and cystic fibrosis, respectively. The EU-funded Twin4Promis project aims to set up a research and training hub in protein misfolding diseases to bridge the gap between the communities that study the misfolding of soluble and integral membrane proteins.
Partners wish to consolidate this research community and address challenges associated with isolation and characterisation of membrane proteins implicated in misfolding diseases. The results generated by the project will provide the groundwork for identifying novel molecules for therapeutic interventions in misfolding diseases associated with integral membrane proteins.
The specific objectives of the Twin4Promis project
Project start date: November 1st, 2022. Project duration: 36 months