Principal Investigators

Prof. Frederic Rousseau and Prof. Joost Schymkowitz

Frederic Rousseau and Joost Schymkowitz have been a scientific duo since 1998. They are Belgian structural biologists and biophysicists affiliated with the Flanders Institute for Biotechnology (VIB) and the University of Leuven (KU Leuven). Joost and Frederic obtained their PhDs from the University of Cambridge, UK and completed post-doctoral research at EMBL in Heidelberg, Germany.

They are currently group leaders at the VIB-KU Leuven Center for Brain & Disease Research and KU Leuven Department of Cellular and Molecular Medicine. Their research group, the Switch Laboratory, integrates computational modeling, biophysics, cell biology and chemical biology with in vivo experiments and analysis of patient tissues to investigate the mechanisms of protein misfolding and aggregation.

Frederic and Joost are also scientific founders of-, and scientific advisors to Aelin Therapuetics, a privately held Belgian biotherapeutics company that develops the therapeutic applications of the Pept-inTM technology, invented in the Switch Lab. They have authored more than 170 peer-reviewed publications in high impact journals, including Nature, Cell and Science, and are inventors on more than 15 patents.