Consortium
Vanderbilt University, USA
Prof. Charles (Chuck) Sanders
Professor of Biochemistry, Aileen M Lange and Annie Mary Lyle Chair of Cardiovascular Research, Vanderbilt School of Medicine Basic Sciences, Vanderbilt University, Nashville, Tennessee, USA
Lab web site: https://structbio.vanderbilt.edu/sanders/
Following undergraduate studies at Milligan College in East Tennessee, Chuck Sanders did his Ph.D. training in enzymology in the lab of Ming-Daw Tsai at the Ohio State University. He then was an NIH Postdoctoral Fellow at Yale University, where he participated in the original development of bicelles under the direction of James H. Prestegard.
He has remained active in the development of novel model membrane media throughout his career. Following a decade studying membrane enzymes at Case Western Reserve University, Chuck moved to Vanderbilt University in 2002, where he has devoted the past 20 years to unraveling the biophysical basis for how folding defects in human membrane proteins such as peripheral myelin 22 (PMP22), the potassium ion channel KCNQ1, and the amyloid precursor protein contribute to human disease. Mutations in these membrane proteins cause Charcot-Marie-Tooth Disease, Long QT Syndrome, and some forms of Alzheimer’s Disease, respectively. To, date Chuck has had the pleasure of advising over 45 Ph.D. students and postdocs. He currently balances his research and training activities with his service as Vice Dean of the Vanderbilt School of Medicine – Basic Sciences and as President of The Protein Society.
