Dr. Georgios Skretas, the Coordinator of the Twin4Promis project, is set to participate in the forthcoming PEGS Europe Conference, a well-known conference in the field of protein and antibody engineering, scheduled to take place in Lisbon, Portugal, from November 14 to 16, 2023. Dr. Skretas will present an invited lecture entitled “Development of Specialized Bacterial Strains for High-Level Production of Recombinant Membrane Proteins.”

Throughout his presentation, Dr. Skretas will impart valuable insights on the development of first- and second-generation E. coli strains, namely, SuptoxD and SuptoxR. He will, also, describe the development of first- and second-generation E. coli SuptoxD and SuptoxR, two specialized strains for high-level recombinant membrane protein (MP) production. These engineered strains can: (1) suppress the toxicity that frequently accompanies MP overexpression, thus enabling enhanced levels of final bacterial biomass; and (2) markedly increase the cellular accumulation of membrane-embedded protein. Combined, these two positive effects result in dramatically enhanced volumetric yields for various prokaryotic and eukaryotic recombinant MPs.