Twin4Promis presents ProteoSeeker, a breakthrough command-line tool that simplifies and accelerates protein discovery through metagenomic analysis. Developed by the Skretas Lab, this open-access resource is designed to empower researchers—regardless of computational expertise—to tap into the vast potential of microbial diversity.

ProteoSeeker streamlines the process of identifying and annotating proteins in complex metagenomic datasets, operating in two user-friendly modes:

• Seek Mode for targeted detection of proteins within user-specified families.

• Taxonomy Mode for mapping the evolutionary origins of the discovered proteins.

By automating key steps in the workflow and minimizing the need for intensive computing infrastructure, ProteoSeeker makes high-quality metagenomic analysis more accessible than ever before. It’s built from the ground up to support both rapid exploration and deep investigation—whether you’re screening for novel enzymes or analyzing microbial community structures.

The tool has already proven its value through the discovery of high-performance biocatalysts, including CA-KR1, a novel carbonic anhydrase with strong potential in CO₂ capture technologies.

Available on GitHub, ProteoSeeker is accompanied by robust documentation – making cutting-edge metagenomic analysis truly approachable.

🔬 Explore the tool: ProteoSeeker website
📖 Full research article in Advanced Science